{"id":5914,"date":"2021-09-16T13:56:28","date_gmt":"2021-09-16T13:56:28","guid":{"rendered":"https:\/\/blog.liquid-themes.com\/?p=5914"},"modified":"2023-02-09T00:45:05","modified_gmt":"2023-02-09T00:45:05","slug":"subcutaneous-trastuzumab-case-achieving-concentration-of-250mg-ml-at-a-syringeable-viscosity-of-18-cp","status":"publish","type":"post","link":"https:\/\/bhamilab.com\/index.php\/2021\/09\/16\/subcutaneous-trastuzumab-case-achieving-concentration-of-250mg-ml-at-a-syringeable-viscosity-of-18-cp\/","title":{"rendered":"Subcutaneous Trastuzumab Case: Achieving concentration of 250mg\/mL at a syringeable viscosity of 18 cP."},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5914\" class=\"elementor elementor-5914\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-44e46675 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"44e46675\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-084fc5f\" data-id=\"084fc5f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dd24dcb elementor-widget elementor-widget-hub_fancy_heading\" data-id=\"dd24dcb\" data-element_type=\"widget\" data-widget_type=\"hub_fancy_heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\n\t\t<div id=\"ld-fancy-heading-69dbb756a1128\" class=\"ld-fancy-heading pos-rel\">\n\t\t\t<p class=\"ld-fh-element d-inline-block pos-rel  lqd-highlight-classic lqd-highlight-grow-left p\"  > Subcutaneous Trastuzumab Case: Achieving concentration of 250mg\/mL at a syringeable viscosity of 18 cP.<\/p>\t\t<\/div>\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62bcc83 elementor-widget elementor-widget-hub_fancy_heading\" data-id=\"62bcc83\" data-element_type=\"widget\" data-widget_type=\"hub_fancy_heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\n\t\t<div id=\"ld-fancy-heading-69dbb756a1bc1\" class=\"ld-fancy-heading pos-rel\">\n\t\t\t<p class=\"ld-fh-element d-inline-block pos-rel  lqd-highlight-classic lqd-highlight-grow-left p\"  > Using only 2 GRAS excipients, BRL has achieved concentrations of over 250mg\/mL with viscosities less than 20cP. Stability data - both in-house and from\u00a0 third party CROs, shows that this high-concentration, low-viscosity formulation of Trastuzumab is physically, chemically and biologically \u00a0stable over a six month duration at normal temperatures. PK\/PD studies show comparable efficacy to the innovator Trastuzumab. This could potentially result in a low-cost, low-volume, high-concentration, subcutaneous version of Trastuzumab.\u00a0<\/p>\t\t<\/div>\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Subcutaneous Trastuzumab Case: Achieving concentration of 250mg\/mL at a syringeable viscosity of 18 cP. Using only 2 GRAS excipients, BRL has achieved concentrations of over 250mg\/mL with viscosities less than 20cP. Stability data &#8211; both in-house and from\u00a0 third party CROs, shows that this high-concentration, low-viscosity formulation of Trastuzumab is physically, chemically and biologically \u00a0stable [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8646,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/bhamilab.com\/index.php\/wp-json\/wp\/v2\/posts\/5914"}],"collection":[{"href":"https:\/\/bhamilab.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bhamilab.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bhamilab.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bhamilab.com\/index.php\/wp-json\/wp\/v2\/comments?post=5914"}],"version-history":[{"count":49,"href":"https:\/\/bhamilab.com\/index.php\/wp-json\/wp\/v2\/posts\/5914\/revisions"}],"predecessor-version":[{"id":8649,"href":"https:\/\/bhamilab.com\/index.php\/wp-json\/wp\/v2\/posts\/5914\/revisions\/8649"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bhamilab.com\/index.php\/wp-json\/wp\/v2\/media\/8646"}],"wp:attachment":[{"href":"https:\/\/bhamilab.com\/index.php\/wp-json\/wp\/v2\/media?parent=5914"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bhamilab.com\/index.php\/wp-json\/wp\/v2\/categories?post=5914"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bhamilab.com\/index.php\/wp-json\/wp\/v2\/tags?post=5914"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}